YDL020C
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| Systematic name | YDL020C |
| Gene name | RPN4 |
| Aliases | SON1, UFD5 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:416705..415110 |
Description of YDL020C: Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses[1][2][3][4]
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References
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- ↑ Owsianik G, et al. (2002) Control of 26S proteasome expression by transcription factors regulating multidrug resistance in Saccharomyces cerevisiae. Mol Microbiol 43(5):1295-308 SGD PMID 11918814
- ↑ Mannhaupt G, et al. (1999) Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast. FEBS Lett 450(1-2):27-34 SGD PMID 10350051
- ↑ Xie Y and Varshavsky A (2001) RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit. Proc Natl Acad Sci U S A 98(6):3056-61 SGD PMID 11248031
- ↑ Ng DT, et al. (2000) The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control. J Cell Biol 150(1):77-88 SGD PMID 10893258
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