YKL197C
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| Systematic name | YKL197C |
| Gene name | PEX1 |
| Aliases | PAS1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:73870..70739 |
Description of YKL197C: AAA-family ATPase peroxin required for peroxisome biogenesis, contains two 230 amino acid ATP-binding AAA cassettes, upregulated in anaerobiosis; Pex1p and Pex6p interact via their N-terminal AAA-cassettes[1][2][3][4]
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Contents
Community Commentary
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DNA and RNA Details
Other DNA and RNA Details
Other Topic: expression
Specifically higher expression in carbon limited chemostat cultures versus carbon excess. [5] [6]
Protein Details
Other Protein Details
Other Topic: Homology
Homology was found, at the sequence and domain-composition level, between several components of the Peroxisomal protein import machinery and components of the Endoplasmic Reticulum Associated Decay (ERAD) pathway. This suggests a common evolutionary origin for both systems and a similar mechanism of action. The homology relationships can be stablished between Pex1,Pex6 and cdc48; Pex2 and Hrd1; Pex4 and Ubc1; and Pex5 and Hrd3. [7] [8]
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References
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- ↑ Birschmann I, et al. (2005) Structural and functional analysis of the interaction of the AAA-peroxins Pex1p and Pex6p. FEBS J 272(1):47-58 SGD PMID 15634331
- ↑ Skoneczny M and Rytka J (2000) Oxygen and haem regulate the synthesis of peroxisomal proteins: catalase A, acyl-CoA oxidase and Pex1p in the yeast Saccharomyces cerevisiae; the regulation of these proteins by oxygen is not mediated by haem. Biochem J 350 Pt 1():313-9 SGD PMID 10926859
- ↑ Erdmann R, et al. (1991) PAS1, a yeast gene required for peroxisome biogenesis, encodes a member of a novel family of putative ATPases. Cell 64(3):499-510 SGD PMID 1825027
- ↑ Krause T, et al. (1994) Effect of site-directed mutagenesis of conserved lysine residues upon Pas1 protein function in peroxisome biogenesis. Yeast 10(12):1613-20 SGD PMID 7725796
- ↑ Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
- ↑ submitted by Viktor Boer on 2003-07-25
- ↑ Gabaldon T, et al. (2006) Origin and evolution of the peroxisomal proteome. Biol Direct 1():8 SGD PMID 16556314
- ↑ submitted by Toni Gabaldon on 2006-04-12
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