YEL021W
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| Systematic name | YEL021W |
| Gene name | URA3 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr V:116167..116970 |
Description of YEL021W: Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound[1][2][3][4][5][6]
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References
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- ↑ Umezu K, et al. (1971) Purification and properties of orotidine-5'-phosphate pyrophosphorylase and orotidine-5'-phosphate decarboxylase from baker's yeast. J Biochem (Tokyo) 70(2):249-62 SGD PMID 5094209
- ↑ Lacroute F (1968) Regulation of pyrimidine biosynthesis in Saccharomyces cerevisiae. J Bacteriol 95(3):824-32 SGD PMID 5651325
- ↑ Jones ME (1992) Orotidylate decarboxylase of yeast and man. Curr Top Cell Regul 33():331-42 SGD PMID 1499340
- ↑ Boeke JD, et al. (1987) 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol 154():164-75 SGD PMID 3323810
- ↑ Boeke JD, et al. (1984) A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol Gen Genet 197(2):345-6 SGD PMID 6394957
- ↑ Alani E and Kleckner N (1987) A new type of fusion analysis applicable to many organisms: protein fusions to the URA3 gene of yeast. Genetics 117(1):5-12 SGD PMID 3311876
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