YNL307C

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Systematic name YNL307C
Gene name MCK1
Aliases YPK1
Feature type ORF, Verified
Coordinates Chr XIV:57573..56446


Description of YNL307C: Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family[1][2][3]




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References

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  1. Shero JH and Hieter P (1991) A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1). Genes Dev 5(4):549-60 SGD PMID 2010084
  2. Neigeborn L and Mitchell AP (1991) The yeast MCK1 gene encodes a protein kinase homolog that activates early meiotic gene expression. Genes Dev 5(4):533-48 SGD PMID 2010083
  3. Lim MY, et al. (1993) Yeast MCK1 protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine. J Biol Chem 268(28):21155-64 SGD PMID 8407952

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