YML125C
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| Systematic name | YML125C |
| Gene name | PGA3 |
| Aliases | NQR1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:21699..20761 |
| Primary SGDID | S000004594 |
Description of YML125C: Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking[1][2][3]
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Community Commentary
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YML125c gene is a plasma membrane NADH-ubiquinone reductase and belongs to the family of cytochrome b5 reductases. Its activity is absolutely dependent of NADH as electron donor and in vivo and in vitro reduce the plasma membrane ubiquinone. The ubiquinone reduction is produced using the one-electron way that involved the superoxide production and is inhibited by DPI, a potent inhibitor of flavodehydrogeneses. Although the null mutant is lethal, the YML125c over expression produces an increased life span extension. We propose the name NQR1 for this gene, NADH ubiQuinone Reductase 1 (Carletrix, personal communication)
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References
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- ↑ Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD PMID 14562095
- ↑ Jimenez-Hidalgo M, et al. (2009) NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 8(2):140-51 SGD PMID 19239415
- ↑ Yu L, et al. (2006) A survey of essential gene function in the yeast cell division cycle. Mol Biol Cell 17(11):4736-47 SGD PMID 16943325
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