YLR139C
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| Systematic name | YLR139C |
| Gene name | SLS1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:423474..421543 |
Description of YLR139C: Mitochondrial membrane protein required for assembly of respiratory-chain enzyme complexes III and IV; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery[1][2][3]
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Community Commentary
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Interactions
Genetic
YLR139C is a suppressor of MTF2
Strain Background: DBY2006
Genotype: ACB1
Mutation type(s): null
The mitochondrial membrane protein Sls1p suppresses the petite phenotype of mtRNA polymerase (Rpo41p) amino-terminal domain and a mtf2/nam1 null mutations, indicating that transcription and tranlation of mtDNA-encoded genes occurs coordinately at the inner mitochondrial membrane. [2] [4]
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References
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- ↑ Rodeheffer MS and Shadel GS (2003) Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis. J Biol Chem 278(20):18695-701 SGD PMID 12637560
- ↑ 2.0 2.1 Bryan AC, et al. (2002) Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression. Genetics 160(1):75-82 SGD PMID 11805046
- ↑ Rouillard JM, et al. (1996) SLS1, a new Saccharomyces cerevisiae gene involved in mitochondrial metabolism, isolated as a syntheticlethal in association with an SSM4 deletion. Mol Gen Genet 252(6):700-8 SGD PMID 8917313
- ↑ submitted by Gerald Shadel on 2003-06-05
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