YOL086W-A
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| Systematic name | YOL086W-A |
| Gene name | MHF1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:159173..159445 |
| Primary SGDID | S000007626 |
Description of YOL086W-A: Protein of unknown function; ortholog of human MHF1, and a component of the heterotetrameric MHF histone-fold complex that in humans interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive[1][2]
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References
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- ↑ Yan Z, et al. (2010) A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell 37(6):865-78 SGD PMID 20347428
- ↑ Yang H, et al. (2012) Saccharomyces Cerevisiae MHF Complex Structurally Resembles the Histones (H3-H4)(2) Heterotetramer and Functions as a Heterotetramer. Structure 20(2):364-70 SGD PMID 22325783
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