YDR285W

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Systematic name YDR285W
Gene name ZIP1
Aliases
Feature type ORF, Verified
Coordinates Chr IV:1032432..1035059


Description of YDR285W: Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate[1][2][3][4]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [2] [5]


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References

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  1. Tsubouchi T and Roeder GS (2005) A synaptonemal complex protein promotes homology-independent centromere coupling. Science 308(5723):870-3 SGD PMID 15879219
  2. 2.0 2.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  3. Storlazzi A, et al. (1996) Synaptonemal complex (SC) component Zip1 plays a role in meiotic recombination independent of SC polymerization along the chromosomes. Proc Natl Acad Sci U S A 93(17):9043-8 SGD PMID 8799151
  4. Dong H and Roeder GS (2000) Organization of the yeast Zip1 protein within the central region of the synaptonemal complex. J Cell Biol 148(3):417-26 SGD PMID 10662769
  5. submitted by Jeff Ubersax on 2004-01-21

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