YDR052C
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| Systematic name | YDR052C |
| Gene name | DBF4 |
| Aliases | DNA52, LSD7 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:560623..558509 |
Description of YDR052C: Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated[1][2]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [4]
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References
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- ↑ Lei M, et al. (1997) Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev 11(24):3365-74 SGD PMID 9407029
- ↑ Cheng L, et al. (1999) Cell cycle regulation of DNA replication initiator factor Dbf4p. Mol Cell Biol 19(6):4270-8 SGD PMID 10330168
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-21
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