YNL068C
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| Systematic name | YNL068C |
| Gene name | FKH2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:498289..495701 |
| Primary SGDID | S000005012 |
Description of YNL068C: Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase[1][2][3][4][5][6][7]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [8]
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References
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- ↑ Hollenhorst PC, et al. (2000) Forkhead genes in transcriptional silencing, cell morphology and the cell cycle. Overlapping and distinct functions for FKH1 and FKH2 in Saccharomyces cerevisiae. Genetics 154(4):1533-48 SGD PMID 10747051
- ↑ Hollenhorst PC, et al. (2001) Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation. Genes Dev 15(18):2445-56 SGD PMID 11562353
- ↑ Kumar R, et al. (2000) Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase. Curr Biol 10(15):896-906 SGD PMID 10959837
- ↑ Morillon A, et al. (2003) Regulation of elongating RNA polymerase II by forkhead transcription factors in yeast. Science 300(5618):492-5 SGD PMID 12702877
- ↑ Pic-Taylor A, et al. (2004) Regulation of cell cycle-specific gene expression through cyclin-dependent kinase-mediated phosphorylation of the forkhead transcription factor Fkh2p. Mol Cell Biol 24(22):10036-46 SGD PMID 15509804
- ↑ 6.0 6.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ Zhu G, et al. (2000) Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth. Nature 406(6791):90-4 SGD PMID 10894548
- ↑ submitted by Jeff Ubersax on 2004-01-29
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