YGR144W
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| Systematic name | YGR144W |
| Gene name | THI4 |
| Aliases | ESP35, MOL1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:780399..781379 |
| Primary SGDID | S000003376 |
Description of YGR144W: Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents[1][2][3][4][5]
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References
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- ↑ Chatterjee A, et al. (2007) Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate. J Am Chem Soc 129(10):2914-22 SGD PMID 17309261
- ↑ Chatterjee A, et al. (2008) Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate. J Am Chem Soc 130(34):11394-8 SGD PMID 18652458
- ↑ Chatterjee A, et al. (2011) Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. Nature 478(7370):542-6 SGD PMID 22031445
- ↑ Machado CR, et al. (1997) Dual role for the yeast THI4 gene in thiamine biosynthesis and DNA damage tolerance. J Mol Biol 273(1):114-21 SGD PMID 9367751
- ↑ Praekelt UM, et al. (1994) Regulation of THI4 (MOL1), a thiamine-biosynthetic gene of Saccharomyces cerevisiae. Yeast 10(4):481-90 SGD PMID 7941734
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