YDR359C

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Systematic name YDR359C
Gene name EAF1
Aliases VID21
Feature type ORF, Verified
Coordinates Chr IV:1194884..1191936
Primary SGDID S000002767


Description of YDR359C: Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1[1][2][3]




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References

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  1. Auger A, et al. (2008) Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants. Mol Cell Biol 28(7):2257-70 SGD PMID 18212047
  2. Jordan PW, et al. (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222 SGD PMID 18069899
  3. Nourani A, et al. (2003) Opposite role of yeast ING family members in p53-dependent transcriptional activation. J Biol Chem 278(21):19171-5 SGD PMID 12672825

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