YDR283C
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| Systematic name | YDR283C |
| Gene name | GCN2 |
| Aliases | AAS1, AAS102, NDR2 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1030049..1025070 |
| Primary SGDID | S000002691 |
Description of YDR283C: Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control[1][2][3][4]
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References
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- ↑ Garcia-Barrio M, et al. (2000) Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation. EMBO J 19(8):1887-99 SGD PMID 10775272
- ↑ Hinnebusch AG and Natarajan K (2002) Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress. Eukaryot Cell 1(1):22-32 SGD PMID 12455968
- ↑ Kubota H, et al. (2001) Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2. J Biol Chem 276(20):17591-6 SGD PMID 11350982
- ↑ Menacho-Marquez M, et al. (2007) Gcn2p regulates a G1/S cell cycle checkpoint in response to DNA damage. Cell Cycle 6(18):2302-5 SGD PMID 17890903
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