YKR008W
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| Systematic name | YKR008W |
| Gene name | RSC4 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:452201..454078 |
| Primary SGDID | S000001716 |
Description of YKR008W: Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p[1][2][3][4][5][6]
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References
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- ↑ Charles GM, et al. (2011) Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Proc Natl Acad Sci U S A () SGD PMID 21673141
- ↑ Kasten M, et al. (2004) Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14. EMBO J 23(6):1348-59 SGD PMID 15014446
- ↑ Lorch Y, et al. (1998) Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell 94(1):29-34 SGD PMID 9674424
- ↑ Neely KE and Workman JL (2002) The complexity of chromatin remodeling and its links to cancer. Biochim Biophys Acta 1603(1):19-29 SGD PMID 12242108
- ↑ Sengupta SM, et al. (2001) The interactions of yeast SWI/SNF and RSC with the nucleosome before and after chromatin remodeling. J Biol Chem 276(16):12636-44 SGD PMID 11304548
- ↑ VanDemark AP, et al. (2007) Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation. Mol Cell 27(5):817-28 SGD PMID 17803945
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