YKL054C

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Systematic name YKL054C
Gene name DEF1
Aliases VID31
Feature type ORF, Verified
Coordinates Chr XI:338753..336537
Primary SGDID S000001537


Description of YKL054C: RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis[1][2][3]




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References

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  1. Jordan PW, et al. (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222 SGD PMID 18069899
  2. Somesh BP, et al. (2005) Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest. Cell 121(6):913-23 SGD PMID 15960978
  3. Woudstra EC, et al. (2002) A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage. Nature 415(6874):929-33 SGD PMID 11859374

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