YER151C
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| Systematic name | YER151C |
| Gene name | UBP3 |
| Aliases | BLM3 |
| Feature type | ORF, Verified |
| Coordinates | Chr V:472424..469686 |
| Primary SGDID | S000000953 |
Description of YER151C: Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity[1][2][3][4][5][6]
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Community Commentary
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blm3-1 is an allele of UBP3 and BLM10 does not act as a suppressor of blm3-1. Further, blm10 null mutants are not sensitive to DNA damaging agents. The original error in cloning Blm10/Blm3 has caused enormous confusion in the proteasome field. [7] [8]
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References
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- ↑ Baker RT, et al. (1992) Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family. J Biol Chem 267(32):23364-75 SGD PMID 1429680
- ↑ Cohen M, et al. (2003) Deubiquitination, a new player in Golgi to endoplasmic reticulum retrograde transport. J Biol Chem 278(52):51989-92 SGD PMID 14593109
- ↑ Cohen M, et al. (2003) Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23. Nat Cell Biol 5(7):661-7 SGD PMID 12778054
- ↑ Moazed D and Johnson D (1996) A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae. Cell 86(4):667-77 SGD PMID 8752220
- ↑ Sole C, et al. (2011) Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress.LID - 10.1038/emboj.2011.227 [doi] EMBO J () SGD PMID 21743437
- ↑ Tsvetanova NG, et al. (2010) Proteome-Wide Search Reveals Unexpected RNA-Binding Proteins in Saccharomyces cerevisiae.LID - e12671 [pii] PLoS One 5(9) SGD PMID 20844764
- ↑ McCullock S, Kinard T, McCullough L, Formosa T (2006) blm3-1 Is an Allele of UBP3, a Ubiquitin Protease that Appears to Act During Transcription of Damaged DNA. J Mol Biol 363(3):660-72
- ↑ Iwanczyk J, Sadre-Bazzaz K, Ferrell K, Kondrashkina E, Formosa T, Hill CP, Ortega J (2006) Structure of the Blm10-20 S proteasome complex by cryo-electron microscopy. Insights into the mechanism of activation of mature yeast proteasomes. J Mol Biol 363(3):648-59
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References
See Help:References on how to add references
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
