YPR140W
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| Systematic name | YPR140W | |
| Gene name | TAZ1 | |
| Aliases | ||
| Feature type | ORF, Verified | |
| Coordinates | Chr XVI:814387..815532 | |
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Description of YPR140W: Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; similar to human tafazzin, which is implicated in Barth syndrome[1][2][3]
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References
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- ↑ Testet E, et al. (2005) Ypr140wp, 'the yeast tafazzin', displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis. Biochem J 387(Pt 3):617-26 SGD PMID 15588229
- ↑ Gu Z, et al. (2004) Aberrant cardiolipin metabolism in the yeast taz1 mutant: a model for Barth syndrome. Mol Microbiol 51(1):149-58 SGD PMID 14651618
- ↑ Neuwald AF (1997) Barth syndrome may be due to an acyltransferase deficiency. Curr Biol 7(8):R465-6 SGD PMID 9259571
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