YNL259C

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Systematic name YNL259C
Gene name ATX1
Aliases
Feature type ORF, Verified
Coordinates Chr XIV:157866..157645
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Description of YNL259C: Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake[1][2]



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References

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  1. Lin SJ, et al. (1997) A role for the Saccharomyces cerevisiae ATX1 gene in copper trafficking and iron transport. J Biol Chem 272(14):9215-20 SGD PMID 9083054
  2. Lin SJ and Culotta VC (1995) The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity. Proc Natl Acad Sci U S A 92(9):3784-8 SGD PMID 7731983

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