YLR035C
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| Systematic name | YLR035C | |
| Gene name | MLH2 | |
| Aliases | ||
| Feature type | ORF, Verified | |
| Coordinates | Chr XII:214457..212370 | |
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Description of YLR035C: Protein required for DNA mismatch repair in mitosis and meiosis; involved in the repair of mutational intermediates; forms a complex with Pms1p and Msh1p to repair mismatched DNA[1][2]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [4]
References
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- ↑ Kolodner R (1996) Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev 10(12):1433-42 SGD PMID 8666228
- ↑ Harfe BD, et al. (2000) Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast. Curr Biol 10(3):145-8 SGD PMID 10679328
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-29
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