YDR399W

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Systematic name YDR399W
Gene name HPT1
Aliases BRA6, HPRT
Feature type ORF, Verified
Coordinates Chr IV:1270061..1270726
Primary SGDID S000002807


Description of YDR399W: Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome[1][2][3]




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References

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  1. Ali LZ and Sloan DL (1982) Studies of the kinetic mechanism of hypoxanthine-guanine phosphoribosyltransferase from yeast. J Biol Chem 257(3):1149-55 SGD PMID 7035445
  2. Ali LZ and Sloan DL (1986) Activation of hypoxanthine/guanine phosphoribosyltransferase from yeast by divalent zinc and nickel ions. J Inorg Biochem 28(4):407-15 SGD PMID 3546595
  3. Nussbaum RL and Caskey CT (1981) Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae. Biochemistry 20(16):4584-90 SGD PMID 6170313

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