YDL003W
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| Systematic name | YDL003W |
| Gene name | MCD1 |
| Aliases | PDS3, RHC21, SCC1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:444681..446381 |
| Primary SGDID | S000002161 |
Description of YDL003W: Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase[1][2]
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Community Commentary
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Mcd1 also involves in hydrogen peroxide-induced apoptosis. Upon induction of cell death, Mcd1 is cleaved and the C-terminal fragment is translocated from nucleus into mitochondria, causing the decrease of mitochondrial membrane potential and the amplification of cell death in a cytochrome c-dependent manner. MBC 19(5):2127-34,2008
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References
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- ↑ Guacci V, et al. (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91(1):47-57 SGD PMID 9335334
- ↑ Yang H, et al. (2008) Cleavage of Mcd1 by Caspase-like Protease Esp1 Promotes Apoptosis in Budding Yeast. Mol Biol Cell 19(5):2127-34 SGD PMID 18321989
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References
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