YDL128W

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Systematic name YDL128W
Gene name VCX1
Aliases HUM1, MNR1
Feature type ORF, Verified
Coordinates Chr IV:232652..233887
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Description of YDL128W: Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter[1][2][3]



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References

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  1. Cunningham KW and Fink GR (1996) Calcineurin inhibits VCX1-dependent H+/Ca2+ exchange and induces Ca2+ ATPases in Saccharomyces cerevisiae. Mol Cell Biol 16(5):2226-37 SGD PMID 8628289
  2. Miseta A, et al. (1999) The vacuolar Ca2+/H+ exchanger Vcx1p/Hum1p tightly controls cytosolic Ca2+ levels in S. cerevisiae. FEBS Lett 451(2):132-6 SGD PMID 10371152
  3. Pozos TC, et al. (1996) The product of HUM1, a novel yeast gene, is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers. Mol Cell Biol 16(7):3730-41 SGD PMID 8668190

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