YLR197W

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Systematic name YLR197W
Gene name NOP56
Aliases SIK1
Feature type ORF, Verified
Coordinates Chr XII:546099..547613
Primary SGDID S000004187


Description of YLR197W: Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects[1][2][3][4]




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References

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  1. Lafontaine DL and Tollervey D (2000) Synthesis and assembly of the box C+D small nucleolar RNPs. Mol Cell Biol 20(8):2650-9 SGD PMID 10733567
  2. Gautier T, et al. (1997) Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. Mol Cell Biol 17(12):7088-98 SGD PMID 9372940
  3. Bogomolnaya LM, et al. (2004) A new enrichment approach identifies genes that alter cell cycle progression in Saccharomyces cerevisiae. Curr Genet 45(6):350-9 SGD PMID 15022016
  4. Hayano T, et al. (2003) Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome. J Biol Chem 278(36):34309-19 SGD PMID 12777385

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