YIL144W
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| Systematic name | YIL144W |
| Gene name | TID3 |
| Aliases | HEC1, NDC80 |
| Feature type | ORF, Verified |
| Coordinates | Chr IX:78074..80149 |
| Primary SGDID | S000001406 |
Description of YIL144W: Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering[1][2][3][4][5][6]
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Contents
Community Commentary
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Alleles, Strains, and Phenotypes
Other Alleles, Strains...
Allele: ndc80-dt
Other Topic: degron tagged mutant
Strain Background: W303a
Genotype: 3053 MATa ura3-1 leu2-2,112 his3-11,15 trp1-1 ade2-1 ndc80-dt :URA3 PGAL10-UBR1:HIS3
Phenotype(s): Loss of function (Null), Recessive, Temperature(Heat) Sensitive
Degron tagged ndc80 mutants are spindle checkpoint proficient. Mutants arrest in mitosis under restrictive conditions when protein is eliminated. Phenotype similar to ndc80-1 missense mutant. [5] [7]
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References
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- ↑ Zheng L, et al. (1999) Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. Mol Cell Biol 19(8):5417-28 SGD PMID 10409732
- ↑ Wigge PA and Kilmartin JV (2001) The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. J Cell Biol 152(2):349-60 SGD PMID 11266451
- ↑ Janke C, et al. (2001) The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control. EMBO J 20(4):777-91 SGD PMID 11179222
- ↑ He X, et al. (2001) Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell 106(2):195-206 SGD PMID 11511347
- ↑ 5.0 5.1 McCleland ML, et al. (2003) The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev 17(1):101-14 SGD PMID 12514103
- ↑ Westermann S, et al. (2003) Architecture of the budding yeast kinetochore reveals a conserved molecular core. J Cell Biol 163(2):215-22 SGD PMID 14581449
- ↑ submitted by Dan Burke on 2003-02-27
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