YNL061W

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Systematic name YNL061W
Gene name NOP2
Aliases YNA1
Feature type ORF, Verified
Coordinates Chr XIV:510541..512397
Primary SGDID S000005005


Description of YNL061W: Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles[1][2][3][4]




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References

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  1. de Beus E, et al. (1994) Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker. J Cell Biol 127(6 Pt 2):1799-813 SGD PMID 7806561
  2. King M, et al. (1999) A conserved motif in the yeast nucleolar protein Nop2p contains an essential cysteine residue. Biochem J 337 ( Pt 1)():29-35 SGD PMID 9854021
  3. Hong B, et al. (2001) Temperature sensitive nop2 alleles defective in synthesis of 25S rRNA and large ribosomal subunits in Saccharomyces cerevisiae. Nucleic Acids Res 29(14):2927-37 SGD PMID 11452018
  4. Horsey EW, et al. (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27 SGD PMID 15100437

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