YJR112W
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| Systematic name | YJR112W |
| Gene name | NNF1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr X:637020..637625 |
| Primary SGDID | S000003873 |
Description of YJR112W: Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation[1][2]
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Community Commentary
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Interactions
Physical
Physical interaction with CSE4
Cse4p immunoprecipitates with Nnf1p. [3] [4]
Physical interaction with DSN1
Nnf1p co-immunoprecipitates Dsn1p. [3] [4]
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References
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- ↑ Shan X, et al. (1997) NNF1 is an essential yeast gene required for proper spindle orientation, nucleolar and nuclear envelope structure and mRNA export. J Cell Sci 110 ( Pt 14):1615-24 SGD PMID 9247195
- ↑ Euskirchen GM (2002) Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae. Eukaryot Cell 1(2):229-40 SGD PMID 12455957
- ↑ 3.0 3.1 Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
- ↑ 4.0 4.1 submitted by Benjamin Pinsky on 2004-03-04
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