YDR113C
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| Systematic name | YDR113C |
| Gene name | PDS1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:681615..680494 |
| Primary SGDID | S000002520 |
Description of YDR113C: Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also required for meiotic progression[1][2][3][4]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [5] [6]
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References
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- ↑ Cohen-Fix O, et al. (1996) Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev 10(24):3081-93 SGD PMID 8985178
- ↑ Cohen-Fix O and Koshland D (1997) The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway. Proc Natl Acad Sci U S A 94(26):14361-6 SGD PMID 9405617
- ↑ Ciosk R, et al. (1998) An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell 93(6):1067-76 SGD PMID 9635435
- ↑ Cooper KF, et al. (2009) Pds1p Is Required for Meiotic Recombination and Prophase I Progression in Saccharomyces cerevisiae. Genetics 181(1):65-79 SGD PMID 19001291
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-21
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