YBR223C
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| Systematic name | YBR223C |
| Gene name | TDP1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:670292..668658 |
| Primary SGDID | S000000427 |
Description of YBR223C: Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI[1][2][3]
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References
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- ↑ He X, et al. (2007) Mutation of a Conserved Active Site Residue Converts Tyrosyl-DNA Phosphodiesterase I into a DNA Topoisomerase I-dependent Poison. J Mol Biol 372(4):1070-81 SGD PMID 17707402
- ↑ Nitiss KC, et al. (2006) Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage. Proc Natl Acad Sci U S A 103(24):8953-8 SGD PMID 16751265
- ↑ Pouliot JJ, et al. (1999) Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes. Science 286(5439):552-5 SGD PMID 10521354
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