YJL156C
Share your knowledge...Edit this entry! <protect>
| Systematic name | YJL156C |
| Gene name | SSY5 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr X:128949..126886 |
| Primary SGDID | S000003692 |
Description of YJL156C: Probable serine protease of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that regulate expression of amino acid permease genes[1][2][3]
</protect>
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
The Fungal Alignment Viewer at SGD indicates that SSY5/YJL156C in S. cerevisiae contains a frame-shift in the 4th-to-last codon (addition of an A), thereby truncating the protein relative to the other sensu stricto strains. In the other strains the ORF is a dozen amino acids longer. The protein and DNA sequences are highly conserved in this region, which contains a serine protease domain. There are a couple of possibilities. 1) The reference genome S288C may contain this sequence and the gene is in fact shorter. 2) The reference sequence for S288C is wrong. Only sequencing of the reference strain can tell.
<protect>
References
See Help:References on how to add references
- ↑ Poulsen P, et al. (2006) Mapping of an internal protease cleavage site in the Ssy5p component of the amino acid sensor of Saccharomyces cerevisiae and functional characterization of the resulting pro- and protease domains by gain-of-function genetics. Eukaryot Cell 5(3):601-8 SGD PMID 16524914
- ↑ Forsberg H, et al. (2001) The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42(1):215-28 SGD PMID 11679080
- ↑ Forsberg H and Ljungdahl PO (2001) Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids. Mol Cell Biol 21(3):814-26 SGD PMID 11154269
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
