YPR067W

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Systematic name YPR067W
Gene name ISA2
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:682217..682774


Description of YPR067W: Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations[1][2][3]




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References

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  1. Rodriguez-Manzaneque MT, et al. (2002) Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes. Mol Biol Cell 13(4):1109-21 SGD PMID 11950925
  2. Pelzer W, et al. (2000) Mitochondrial Isa2p plays a crucial role in the maturation of cellular iron-sulfur proteins. FEBS Lett 476(3):134-9 SGD PMID 10913600
  3. Jensen LT and Culotta VC (2000) Role of Saccharomyces cerevisiae ISA1 and ISA2 in iron homeostasis. Mol Cell Biol 20(11):3918-27 SGD PMID 10805735

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