YPL094C
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Systematic name | YPL094C | |
Gene name | SEC62 | |
Aliases | LPG14 | |
Feature type | ORF, Verified | |
Coordinates | Chr XVI:370660..369836 | |
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Description of YPL094C: Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER[1][2][3]
DNA and RNA Details
Transcription Start
Transcription start(s): 369837,370712 Transcription starts at co-ordinate 370694 or 370695 [1] [4]
Interactions
Two Hybrid
Two Hybrid interaction with SEC63
Amino terminal domain of Sec62p (residues 1-149) interacts with c-terminal 39 residues of Sec63p [1] [4]
Protein Details
Mature Length (direct evidence)
Protein length: 274 aa The authentic translation start occurs at the AUG codon located at co-ordinate 370658 and not at the cryptic AUG located 27bp upstream (370685). The primary translation product is thus 274 amino acid residues in length and not 283 as previously supposed. [1] [4]
Community Commentary
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DNA and RNA Details
Transcription Start
Transcription start(s): 369837,370712 Transcription starts at co-ordinate 370694 or 370695 [1] [4]
Interactions
Two Hybrid
Two Hybrid interaction with SEC63
Amino terminal domain of Sec62p (residues 1-149) interacts with c-terminal 39 residues of Sec63p [1] [4]
Protein Details
Mature Length (direct evidence)
Protein length: 274 aa The authentic translation start occurs at the AUG codon located at co-ordinate 370658 and not at the cryptic AUG located 27bp upstream (370685). The primary translation product is thus 274 amino acid residues in length and not 283 as previously supposed. [1] [4]
References
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- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 SGD PMID 12518317
- ↑ Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 SGD PMID 11226176
- ↑ Deshaies RJ and Schekman R (1989) SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum. J Cell Biol 109(6 Pt 1):2653-64 SGD PMID 2687286
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 submitted by Colin Stirling on 2003-02-05
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