YKL019W

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Systematic name YKL019W
Gene name RAM2
Aliases
Feature type ORF, Verified
Coordinates Chr XI:402211..403161
Primary SGDID S000001502


Description of YKL019W: Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor[1][2][3][4]




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References

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  1. Mayer ML, et al. (1992) CDC43 and RAM2 encode the polypeptide subunits of a yeast type I protein geranylgeranyltransferase. J Biol Chem 267(29):20589-93 SGD PMID 1400380
  2. Gomez R, et al. (1993) Purified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart. Biochem J 289 ( Pt 1):25-31 SGD PMID 8424764
  3. He B, et al. (1991) RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins. Proc Natl Acad Sci U S A 88(24):11373-7 SGD PMID 1763050
  4. Kohl NE, et al. (1991) Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases. J Biol Chem 266(28):18884-8 SGD PMID 1918005

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