YDL003W
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| Systematic name | YDL003W |
| Gene name | MCD1 |
| Aliases | PDS3, RHC21, SCC1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:444680..446380 |
| Primary SGDID | S000002161 |
Description of YDL003W: Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase[1]
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Community Commentary
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Mcd1 also involves in hydrogen peroxide-induced apoptosis. Upon induction of cell death, Mcd1 is cleaved and the C-terminal fragment is translocated from nucleus into mitochondria, causing the decrease of mitochondrial membrane potential and the amplification of cell death in a cytochrome c-dependent manner. MBC 19(5):2127-34,2008
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