YKR089C
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| Systematic name | YKR089C | |
| Gene name | TGL4 | |
| Aliases | STC1 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr XI:608007..605275 | |
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Description of YKR089C: Triacylglycerol lipase involved in triacylglycerol mobilization and degradation; found in lipid particles; potential Cdc28p substrate[1][2][3]
Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Together with: TGL3
Phenotype(s): Loss of function (Null), Recessive, Viable
tgl3 tgl4 double mutants are unable to degrade triglycerides in lag and early log-phases of growth [1] [4]
Protein Details
Protein Function/Process
Together with: TGL3
Triglyceride lipase activity; Functional complementation of tgl4 mutants by murine ATGL, Adipose Triglyceride Lipase [1] [4]
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [5]
Community Commentary
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Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Together with: TGL3
Phenotype(s): Loss of function (Null), Recessive, Viable
tgl3 tgl4 double mutants are unable to degrade triglycerides in lag and early log-phases of growth [1] [4]
Protein Details
Protein Function/Process
Together with: TGL3
Triglyceride lipase activity; Functional complementation of tgl4 mutants by murine ATGL, Adipose Triglyceride Lipase [1] [4]
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [5]
References
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- ↑ 1.0 1.1 1.2 1.3 1.4 Kurat CF, et al. (2006) Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J Biol Chem 281(1):491-500 SGD PMID 16267052
- ↑ Athenstaedt K and Daum G (2005) Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles. J Biol Chem 280(45):37301-9 SGD PMID 16135509
- ↑ 3.0 3.1 3.2 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
SGD PMID 14574415 Cite error: Invalid
<ref>tag; name "S000074306" defined multiple times with different content Cite error: Invalid<ref>tag; name "S000074306" defined multiple times with different content - ↑ 4.0 4.1 4.2 4.3 submitted by Sepp D. Kohlwein on 2006-05-22
- ↑ 5.0 5.1 submitted by Jeff Ubersax on 2004-01-29
See Help:Categories on how to add the wiki page for this gene to a Category
- Pages with reference errors
- ORF
- ORF, Verified
- Topic:Alleles, Strains, and Phenotypes
- Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains
- Phenotype:Loss of function (Null)
- Phenotype:Recessive
- Phenotype:Viable
- Topic:Protein Details
- Topic:Protein Details:Protein Function/Process
- Topic:Protein Details:Protein Modification
- Modification:Phosphorylation
