YDR419W

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Systematic name YDR419W
Gene name RAD30
Aliases DBH1
Feature type ORF, Verified
Coordinates Chr IV:1303166..1305064


Description of YDR419W: DNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteins[1][2][3][4]




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References

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  1. Washington MT, et al. (2003) The mechanism of nucleotide incorporation by human DNA polymerase eta differs from that of the yeast enzyme. Mol Cell Biol 23(22):8316-22 SGD PMID 14585988
  2. Prakash S and Prakash L (2002) Translesion DNA synthesis in eukaryotes: a one- or two-polymerase affair. Genes Dev 16(15):1872-83 SGD PMID 12154119
  3. Yuan F, et al. (2000) Specificity of DNA lesion bypass by the yeast DNA polymerase eta. J Biol Chem 275(11):8233-9 SGD PMID 10713149
  4. Johnson RE, et al. (1999) Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta. Science 283(5404):1001-4 SGD PMID 9974380

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