YNL088W
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| Systematic name | YNL088W |
| Gene name | TOP2 |
| Aliases | TOR3, TRF3 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:457706..461992 |
| Primary SGDID | S000005032 |
Description of YNL088W: Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis[1][2][3][4]
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References
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- ↑ Roca J (1995) The mechanisms of DNA topoisomerases. Trends Biochem Sci 20(4):156-60 SGD PMID 7770916
- ↑ Wang JC (1996) DNA topoisomerases. Annu Rev Biochem 65():635-92 SGD PMID 8811192
- ↑ Goto T and Wang JC (1984) Yeast DNA topoisomerase II is encoded by a single-copy, essential gene. Cell 36(4):1073-80 SGD PMID 6323017
- ↑ Klein F, et al. (1992) Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast. J Cell Biol 117(5):935-48 SGD PMID 1315786
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