YLR384C

From SGD-Wiki
Revision as of 08:46, 27 February 2007 by SGDwikiBot (talk | contribs) (Automated import of articles)
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YLR384C
Gene name IKI3
Aliases ELP1, TOT1
Feature type ORF, Verified
Coordinates Chr XII:892900..888851
Primary SGDID S000004376


Description of YLR384C: Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)[1][2][3][4]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!




<protect>

References

See Help:References on how to add references

  1. Esberg A, et al. (2006) Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis. Mol Cell 24(1):139-48 SGD PMID 17018299
  2. Rahl PB, et al. (2005) Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Mol Cell 17(6):841-53 SGD PMID 15780940
  3. Frohloff F, et al. (2003) Subunit communications crucial for the functional integrity of the yeast RNA polymerase II elongator (gamma-toxin target (TOT)) complex. J Biol Chem 278(2):956-61 SGD PMID 12424236
  4. Kishida M, et al. (1996) Isolation and genetic characterization of pGKL killer-insensitive mutants (iki) from Saccharomyces cerevisiae. Biosci Biotechnol Biochem 60(5):798-801 SGD PMID 8704309

See Help:Categories on how to add the wiki page for this gene to a Category </protect>