YOR008C
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| Systematic name | YOR008C |
| Gene name | SLG1 |
| Aliases | HCS77, WSC1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:342414..341278 |
| Primary SGDID | S000005534 |
Description of YOR008C: Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response[1][2][3][4]
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Community Commentary
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Transmembrane Domain GxxxG
The transmembrane domain of Slg1p/Wsc1p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with vGaivGGvvGGvvG. The presence of multiple, overlapping GxxxG motifs [5] strongly indicates that Slg1p/Wsc1p multimerises.
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References
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- ↑ Gualtieri T, et al. (2004) The cell wall sensor Wsc1p is involved in reorganization of actin cytoskeleton in response to hypo-osmotic shock in Saccharomyces cerevisiae. Yeast 21(13):1107-20 SGD PMID 15484288
- ↑ Lodder AL, et al. (1999) Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae. Genetics 152(4):1487-99 SGD PMID 10430578
- ↑ Mao K, et al. (2011) Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol 193(4):755-67 SGD PMID 21576396
- ↑ Nanduri J and Tartakoff AM (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9 SGD PMID 11545731
- ↑ Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242
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References
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