YIL031W
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| Systematic name | YIL031W |
| Gene name | ULP2 |
| Aliases | SMT4 |
| Feature type | ORF, Verified |
| Coordinates | Chr IX:292632..295736 |
| Primary SGDID | S000001293 |
Description of YIL031W: Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate[1][2][3]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [1] [4]
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References
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- ↑ 1.0 1.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ Bachant J, et al. (2002) The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. Mol Cell 9(6):1169-82 SGD PMID 12086615
- ↑ Li SJ and Hochstrasser M (2000) The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein. Mol Cell Biol 20(7):2367-77 SGD PMID 10713161
- ↑ submitted by Jeff Ubersax on 2004-01-27
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