YBR245C
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| Systematic name | YBR245C |
| Gene name | ISW1 |
| Aliases | SGN2 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:711539..708150 |
| Primary SGDID | S000000449 |
Description of YBR245C: ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions[1][2][3][4][5]
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References
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- ↑ Mellor J and Morillon A (2004) ISWI complexes in Saccharomyces cerevisiae. Biochim Biophys Acta 1677(1-3):100-12 SGD PMID 15020051
- ↑ Morillon A, et al. (2003) Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II. Cell 115(4):425-35 SGD PMID 14622597
- ↑ Smolle M, et al. (2012) Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange.LID - 10.1038/nsmb.2312 [doi] Nat Struct Mol Biol () SGD PMID 22922743
- ↑ Tsukiyama T, et al. (1999) Characterization of the imitation switch subfamily of ATP-dependent chromatin-remodeling factors in Saccharomyces cerevisiae. Genes Dev 13(6):686-97 SGD PMID 10090725
- ↑ Vary JC Jr, et al. (2003) Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol 23(1):80-91 SGD PMID 12482963
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