YNR046W
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| Systematic name | YNR046W |
| Gene name | TRM112 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:707788..708195 |
| Primary SGDID | S000005329 |
Description of YNR046W: Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin[1][2][3][4]
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References
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- ↑ Figaro S, et al. (2012) Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575. Mol Cell Biol () SGD PMID 22493060
- ↑ Heurgue-Hamard V, et al. (2006) The Zinc Finger Protein Ynr046w Is Plurifunctional and a Component of the eRF1 Methyltransferase in Yeast. J Biol Chem 281(47):36140-8 SGD PMID 17008308
- ↑ Purushothaman SK, et al. (2005) Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA. Mol Cell Biol 25(11):4359-70 SGD PMID 15899842
- ↑ Studte P, et al. (2008) tRNA and protein methylase complexes mediate zymocin toxicity in yeast. Mol Microbiol 69(5):1266-77 SGD PMID 18657261
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