YMR165C
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| Systematic name | YMR165C |
| Gene name | PAH1 |
| Aliases | SMP2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:592628..590040 |
| Primary SGDID | S000004775 |
Description of YMR165C: Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol, responsible for de novo lipid synthesis and formation of lipid droplets; homologous to mammalian lipin 1; multiple phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance, while dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane localization resulting in increased substrate catalysis[1][2][3]
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References
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- ↑ Adeyo O, et al. (2011) The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets. J Cell Biol 192(6):1043-55 SGD PMID 21422231
- ↑ Choi HS, et al. (2012) Pho85p-Pho80p phosphorylation of yeast Pah1p phosphatidate phosphatase regulates its activity, location, abundance, and function in lipid metabolism. J Biol Chem () SGD PMID 22334681
- ↑ Han GS, et al. (2006) The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme. J Biol Chem 281(14):9210-8 SGD PMID 16467296
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