YOR156C
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| Systematic name | YOR156C |
| Gene name | NFI1 |
| Aliases | SIZ2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:630540..628360 |
| Primary SGDID | S000005682 |
Description of YOR156C: SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length[1][2][3][4]
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References
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- ↑ Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
- ↑ Ferreira HC, et al. (2011) The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.LID - 10.1038/ncb2263 [doi] Nat Cell Biol () SGD PMID 21666682
- ↑ Hochstrasser M (2001) SP-RING for SUMO: new functions bloom for a ubiquitin-like protein. Cell 107(1):5-8 SGD PMID 11595179
- ↑ Johnson ES and Gupta AA (2001) An E3-like factor that promotes SUMO conjugation to the yeast septins. Cell 106(6):735-44 SGD PMID 11572779
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