YOR005C
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| Systematic name | YOR005C |
| Gene name | DNL4 |
| Aliases | LIG4 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:337343..334509 |
| Primary SGDID | S000005531 |
Description of YOR005C: DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth[1][2][3][4][5]
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Community Commentary
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References
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- ↑ Frank-Vaillant M and Marcand S (2001) NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the ligase IV pathway. Genes Dev 15(22):3005-12 SGD PMID 11711435
- ↑ Liti G and Louis EJ (2003) NEJ1 prevents NHEJ-dependent telomere fusions in yeast without telomerase. Mol Cell 11(5):1373-8 SGD PMID 12769859
- ↑ Ramos W, et al. (1998) Biochemical and genetic characterization of the DNA ligase encoded by Saccharomyces cerevisiae open reading frame YOR005c, a homolog of mammalian DNA ligase IV. Nucleic Acids Res 26(24):5676-83 SGD PMID 9837999
- ↑ Schar P, et al. (1997) A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks. Genes Dev 11(15):1912-24 SGD PMID 9271115
- ↑ Wilson TE, et al. (1997) Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature 388(6641):495-8 SGD PMID 9242411
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