YOL025W
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| Systematic name | YOL025W |
| Gene name | LAG2 |
| Aliases | ECM36 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:274957..276939 |
| Primary SGDID | S000005385 |
Description of YOL025W: Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1[1][2][3]
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References
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- ↑ Childress AM, et al. (1996) LAG2, a gene that determines yeast longevity. Microbiology 142 ( Pt 8):2289-97 SGD PMID 8760941
- ↑ Liu Y, et al. (2009) A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. EMBO J 28(21):3366-77 SGD PMID 19763088
- ↑ Siergiejuk E, et al. (2009) Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. EMBO J 28(24):3845-56 SGD PMID 19942853
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