YNL064C
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| Systematic name | YNL064C |
| Gene name | YDJ1 |
| Aliases | HSP40, MAS5 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:507097..505868 |
| Primary SGDID | S000005008 |
Description of YNL064C: Type I HSP40 co-chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family[1][2][3][4][5][6]
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Interactions
Genetic
YNL064C is suppressed by FES1
Strain Background: W303 (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study)
Mutation type(s): point mutation (ydj1-151), deletion
The thermosensitivity and cycloheximide sensitivity of the single deltafes1 and ydj1-151 mutants is partly suppressed in the double mutant. [7] [8]
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References
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- ↑ Caplan AJ and Douglas MG (1991) Characterization of YDJ1: a yeast homologue of the bacterial dnaJ protein. J Cell Biol 114(4):609-21 SGD PMID 1869583
- ↑ Caplan AJ, et al. (1992) YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism. Cell 71(7):1143-55 SGD PMID 1473150
- ↑ Hon T, et al. (2001) The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme. Mol Cell Biol 21(23):7923-32 SGD PMID 11689685
- ↑ Kimura Y, et al. (1995) Role of the protein chaperone YDJ1 in establishing Hsp90-mediated signal transduction pathways. Science 268(5215):1362-5 SGD PMID 7761857
- ↑ Summers DW, et al. (2009) Prion propagation by Hsp40 molecular chaperones. Prion 3(2):59-64 SGD PMID 19535913
- ↑ Ziegelhoffer T, et al. (1995) The dissociation of ATP from hsp70 of Saccharomyces cerevisiae is stimulated by both Ydj1p and peptide substrates. J Biol Chem 270(18):10412-9 SGD PMID 7737974
- ↑ Kabani M, et al. (2002) Nucleotide exchange factor for the yeast Hsp70 molecular chaperone Ssa1p. Mol Cell Biol 22(13):4677-89 SGD PMID 12052876
- ↑ submitted by Mehdi Kabani on 2003-03-31
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