YGL208W
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| Systematic name | YGL208W |
| Gene name | SIP2 |
| Aliases | SPM2 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:97342..98589 |
Description of YGL208W: One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane[1][2][3][4]
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Contents
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Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4597
Together with: NRG2, NRG1, SIP1, GAL83
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. [5] [6]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, SIP1, GAL83, MUC1
Phenotype(s): Loss of function (Null)
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [5] [6]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: REG1, SIP1, GAL83, MUC1
Phenotype(s): Loss of function (Null)
Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. [5] [6]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, SIP1, GAL83, MUC1
Phenotype(s): Loss of function (Null)
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [5] [6]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4597
Together with: NRG2, NRG1, SIP1, GAL83
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. [5] [6]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4597
Together with: NRG2, NRG1, SIP1, GAL83
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. [5] [6]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: REG1, SIP1, GAL83, MUC1
Phenotype(s): Loss of function (Null)
Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. [5] [6]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4597
Together with: NRG2, NRG1, SIP1, GAL83
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. [5] [6]
DNA and RNA Details
Other DNA and RNA Details
Other Topic: expression
Specifically higher expression in carbon limited chemostat cultures versus carbon excess. [7] [8]
Protein Details
Protein Function/Process
One of three alternative beta subunits of the Snf1 kinase complex [3] [9]
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References
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- ↑ Lin SS, et al. (2003) Sip2, an N-myristoylated beta subunit of Snf1 kinase, regulates aging in Saccharomyces cerevisiae by affecting cellular histone kinase activity, recombination at rDNA loci, and silencing. J Biol Chem 278(15):13390-7 SGD PMID 12562756
- ↑ Vincent O, et al. (2001) Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism. Genes Dev 15(9):1104-14 SGD PMID 11331606
- ↑ 3.0 3.1 Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43 SGD PMID 10990457
- ↑ Ashrafi K, et al. (2000) Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev 14(15):1872-85 SGD PMID 10921902
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 SGD PMID 12556493
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 submitted by Valmik K. Vyas on 2003-03-27
- ↑ Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
- ↑ submitted by Viktor Boer on 2003-07-25
- ↑ submitted by Martin C. Schmidt on 2003-02-17
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
- ORF
- ORF, Verified
- Topic:Alleles, Strains, and Phenotypes
- Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains
- Phenotype:Loss of function (Null)
- Topic:DNA and RNA Details
- Topic:DNA and RNA Details:Other DNA and RNA Details
- Topic:expression
- Topic:Protein Details
- Topic:Protein Details:Protein Function/Process
