YOL115W

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Systematic name YOL115W
Gene name PAP2
Aliases TRF4
Feature type ORF, Verified
Coordinates Chr XV:101475..103229
Primary SGDID S000005475


Description of YOL115W: Non-canonical poly(A) polymerase, involved in nuclear RNA quality control as a component of the TRAMP complex; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; overlapping functions with Trf5p[1][2][3][4]




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References

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  1. Vanacova S, et al. (2005) A new yeast poly(A) polymerase complex involved in RNA quality control. PLoS Biol 3(6):e189 SGD PMID 15828860
  2. LaCava J, et al. (2005) RNA degradation by the exosome is promoted by a nuclear polyadenylation complex. Cell 121(5):713-24 SGD PMID 15935758
  3. Wyers F, et al. (2005) Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase. Cell 121(5):725-37 SGD PMID 15935759
  4. Gellon L, et al. (2008) Intrinsic 5'-deoxyribose-5-phosphate lyase activity in Saccharomyces cerevisiae Trf4 protein with a possible role in base excision DNA repair. DNA Repair (Amst) 7(2):187-98 SGD PMID 17983848

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