YNL186W
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| Systematic name | YNL186W |
| Gene name | UBP10 |
| Aliases | DOT4 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:289500..291878 |
| Primary SGDID | S000005130 |
Description of YNL186W: Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus[1][2][3]
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Community Commentary
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Interactions
Two Hybrid
Two Hybrid interaction with SIR4
The N-terminal 250 aa of Ubp10p interacts with the C-terminus of Sir4p (residues 839-1358). [2] [4]
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References
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- ↑ Kahana A (2001) The deubiquitinating enzyme Dot4p is involved in regulating nutrient uptake. Biochem Biophys Res Commun 282(4):916-20 SGD PMID 11352638
- ↑ 2.0 2.1 Kahana A and Gottschling DE (1999) DOT4 links silencing and cell growth in Saccharomyces cerevisiae. Mol Cell Biol 19(10):6608-20 SGD PMID 10490600
- ↑ Singer MS, et al. (1998) Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics 150(2):613-32 SGD PMID 9755194
- ↑ submitted by Daniel E. Gottschling on 2003-03-17
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