YBR263W
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| Systematic name | YBR263W |
| Gene name | SHM1 |
| Aliases | SHMT1, TMP3 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:736259..737731 |
| Primary SGDID | S000000467 |
Description of YBR263W: Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine[1][2][3]
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References
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- ↑ Taylor BV, et al. (1993) Cloning of the genes encoding the serine hydroxymethyltransferases from Saccharomyces cerevisiae. Adv Exp Med Biol 338:711-4 SGD PMID 8304212
- ↑ McNeil JB, et al. (1994) Cloning and molecular characterization of three genes, including two genes encoding serine hydroxymethyltransferases, whose inactivation is required to render yeast auxotrophic for glycine. J Biol Chem 269(12):9155-65 SGD PMID 8132653
- ↑ Kastanos EK, et al. (1997) Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae. Biochemistry 36(48):14956-64 SGD PMID 9398220
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